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MALT lymphoma
4 associated genes
16 signs/symptoms
PROTEIN INTERACTIONS: 1
COMMON SIGNS: 3
Blau syndrome
1 OMIM reference -
1 associated gene
43 signs/symptoms
MALT lymphoma
Blau syndrome

BIRC3
(UniProt - OMIM)
 NOD2
(UniProt - OMIM)
FOXP1
(UniProt - OMIM)
IGH
(UniProt)
MALT1
(UniProt - OMIM)

INTERACTOME
ASSOCIATIONS
(click on a score value to see the evidence)
BIRC3
(0.63)
NOD2


Citations in the biomedical literature:


MALT lymphoma
BIRC3 FOXP1 IGH MALT1
Blau syndrome
NOD2



MALT lymphoma
Blau syndrome

Synonym(s):
- Extranodal marginal zone B-cell lymphoma
- MALToma
- Mucosa-associated lymphatic tissue lymphoma
- Mucosa-associated lymphoid tissue lymphoma
Synonym(s):
(no synonyms)
Classification (Orphanet):
- Rare hematologic disease
- Rare oncologic disease
Classification (Orphanet):
- Rare eye disease
- Rare genetic disease
- Rare immune disease
- Rare respiratory disease
- Rare skin disease
- Rare systemic or rheumatologic disease
Classification (ICD10):
- Neoplasms -
Classification (ICD10):
(no data available)
Epidemiological data:
Class of prevalence: 1-9 / 100 000
Average age onset: adulthood
Average age of death: normal
Type of inheritance: multigenic/multifactorial
Epidemiological data:
Class of prevalence: <1 / 1 000 000
Average age onset: neonatal/infancy
Average age of death: -
Type of inheritance: autosomal dominant
External references:
No OMIM references
No MeSH references
External references:
1 OMIM reference -
No MeSH references
COMMON
SIGNS 		- Chronic uveitis / blepharitis / episcleritis / scleritis / conjonctivitis / keratitis
- Fever / chilling
- Lymphadenopathy / polyadenopathies

MALT lymphoma
Blau syndrome

Very frequent
- Asthenia / fatigue / weakness
- Epigastralgia / heartburn / gastric / duodenal ulcer / gastritis
- Hematologic / blood / lymphatic cancer
- Hyperhidrosis / increased sweating
- Lung / pulmonary infiltrates
- Nausea / vomiting / regurgitation / merycism / hyperemesis
- Weight loss / loss of appetite / break in weight curve / general health alteration

Frequent
- Constipation

Occasional
- Acute abdominal pain / colic
- Defect / anomaly of lacrimal system
- Mediastinal / hilar adenopathies
- Repeat respiratory infections
- Thyroid anomalies


Very frequent
- Arthritis / synovitis / synovial proliferation
- Articular / joint pain / arthralgia
- Autosomal dominant inheritance
- Biological inflammatory syndrome / increased erythrocyte sedimentation rate / CRP
- Cutaneous rash
- Erythema / erythematous lesions / erythroderma / polymorphous erythema
- Follicular / erythematous / edematous papules / milium
- Hydrarthrosis / articular / joint effusion
- Macules
- Restricted joint mobility / joint stiffness / ankylosis

Frequent
- Camptodactyly of fingers
- Cataract / lens opacification
- Dry / squaly skin / exfoliation
- Glaucoma
- Photophobia

Occasional
- Anaemia
- Anomaly / ectopia / hypoplasia / atresia of salivary glands / salivary duct
- Aortic root dilatation / dilation / aneurysm
- Central neuropathy
- Choroidal anomalies / atrophy / choroideremia
- Chronic arterial hypertension
- Chronic skin infection / ulcerations / ulcers / cancrum
- Facial palsy
- Functional anomalies of the liver and the biliary tract
- Ichthyosis / ichthyosiform dermatitis
- Interstitial nephropathy
- Kidney / renal neoplasm / tumor / carcinoma / cancer
- Mouth dryness / xerostomia
- Optic nerve anomaly / optic atrophy / anomaly of the papilla
- Pericardium anomalies / pericarditis / absence / cysts / pericardial effusion
- Pulmonary hypertension
- Purpura / petichiae
- Renal disease / nephropathy
- Renal failure
- Respiratory distress / dyspnea / respiratory failure / lung volume reduction
- Retinopathy
- Retrobulbar optic neuritis
- Splenomegaly
- Vascularitis / vasculitides / arteritis
- Visual loss / blindness / amblyopia